Antivirus might be useless, but if it can’t run, then it won’t be able to do anything. VoodooShield blocks almost everything from running. Sandboxie puts your browser or whatever in a sandbox. So if it does run, it’ll be in a sandbox.
Most of my browsing is done from Linux now, there’s a free alternative to Sandboxie for Linux, it’s called Firejail.
Good luck teaching anyone how to use VoodooShield or Sandboxie.